In 1987, sudden and intense rainfall caused the river to surge at an unprecedented rate in mid-July, leading to a tragedy that killed 10 campers at Pot O' Gold Christian Camp, a summer camp near Comfort, Texas. The campers drowned when their bus attempted to evacuate them and was overtaken by floodwater.

Rescuers were searching for more than two dozen girls missing from a summer camp in Texas after a flash flood killed at least 50 people, 15 of them children. The Guadalupe River that runs through the Hill Country in central south Texas rose by 26ft (8 metres) in 45 minutes in the early hours of Friday,