The Cleveland Guardians defeated the Baltimore Orioles 6-3 in a competitive Orioles vs Guardians matchup on July 22, 2025, at Progressive Field, as seen in the sports card above. José Ramírez’s first-inning home run set the tone,

BOTTOM LINE: The Cleveland Guardians, on a three-game home winning streak, host the Baltimore Orioles. Cleveland is 50-50 overall and 24-24 at home. The Guardians have gone 18-10 in games when they hit two or more home runs.

The Guardians took the second of the four-game series with the Orioles, 6-3, a day after winning the opener, 10-5. Cleveland is on a three-game winning streak, 4-1 in the past five and 8-2 over the last 10, so the Guardians are getting hot, while the O’s are 1-6 in the last seven.

Preview the July 23 matchup between the Cleveland Guardians and Baltimore Orioles with odds over/under, game spread, betting lines and more.

Cleveland Guardians fans haven't forgotten about Josh Naylor, but they do feel much better about the trade that sent him to the Arizona Diamondbacks last Dec. 21.

The Guardians used a left-handed starter and stacked nine lefties and/or switch-hitters in their lineup to beat the Orioles on Tuesday.

Jose Ramirez homered for the second straight game and Kyle Manzardo and Brayan Rocchio drove in two runs apiece as the surging Cleveland Guardians beat the visiting Baltimore Orioles 6-3 on Tuesday night.

José Ramírez, Bo Naylor and Kyle Manzardo go deep as the Guardians extend their streak to 11 straight games with a home run.