The structure of a key enzyme involved in protein production is revealed by cryo-electron microscopy (cryo-EM). Using cryo-EM, researchers at Goethe University (Frankfurt, Germany) shed light on ...

Thus, ArcS is an unprecedented tRNA modification enzyme that can act on a nucleoside as the substrate. With the development of mRNA vaccines for COVID-19, modified nucleosides like pseudouridine and 1 ...

In cells, transfer RNA (tRNA) translates genetic information from the encoding messenger RNA (mRNA) for protein synthesis. New results from ultrafast spectroscopy and in-depth theoretical calculations ...

Analyses of the secondary structures suggest that both mascRNA and menRNA have regions analogous to the acceptor stem (AS) and T stem-loop (TSL) of tRNA. However, the D stem-loop (DSL) regions are ...

tRNAs have a distinct cloverleaf secondary structure and an L-shaped tertiary structure. The cloverleaf structure is formed by the folding of the single-stranded tRNA molecule, which is typically ...

To have an in-detail 3D mapping of its conformational changes induced by Mg 2+ and tRNA binding, we first characterize the dynamics of individual stem of T99 using smFRET (Fig. 3). Fig. 3: Mg 2+ and ...

In all living organisms, the biomolecule transfer RNA (tRNA) plays a fundamental role in protein production. tRNAs are generated from precursor molecules in several steps. The enzyme tRNA splicing ...

Prostate cancer is the second-most common cancer in men. A new study from Thomas Jefferson University uncovered a new potential therapeutic target in tiny molecules called tRNA halves. "Because tRNA ...

Many viruses have genomes made of RNA. In human cells, messenger RNA (mRNA) molecules act as intermediates; cellular machinery copies a DNA sequence into mRNA so that it can then be translated into a ...

When Daniel Fischer cofounded Tevard Biosciences in 2017, he wasn’t trying to bet on the next hot RNA technology. His interest was more personal. His daughter Natasha has Dravet syndrome, a rare form ...

In cells transfer RNA (tRNA) translates genetic information from the encoding messenger RNA (mRNA) for protein synthesis. New results from ultrafast spectroscopy and in-depth theoretical calculations ...