With a win tonight, the 49ers’ odds of making the playoffs move from 83 percent from 89 percent in The Athletic’s NFL Playoff Simulator. With the Rams firmly atop the NFC West (and, now, the entire NFC), San Francisco is overwhelmingly likely to make the playoffs as a wild-card team.

The San Francisco 49ers (7-4) host the Carolina Panthers (6-5) on Monday Night Football in a key battle for NFC playoff positioning.

The Carolina Panthers and the San Francisco 49ers take the field for NFL Monday Night Football tonight in Week 12. MNF start time, schedule and how to watch.

The Carolina Panthers face the San Francisco 49ers on Monday, Nov. 24, 2025 at Levi’s Stadium in Santa Clara, California.

The Panthers hit the road to take on the 49ers on Monday Night Football. The 49ers/Panthers game starts at 8:15 p.m. ET on ESPN. Yes! Peyton and Eli will be on ESPN2 for tonight’s 49ers/Panthers matchup.

As both teams jockey for position in the playoff standings, the San Francsico 49ers battle the Carolina Panthers on Monday Night Football today. Find out how to watch for free.

The San Francisco 49ers (7-4) will take on the Carolina Panthers (6-5) at Levi Stadium in Santa Clara, California, on Monday, Nov. 24.

49ers vs. Panthers will be on "Monday Night Football" in Week 12, which will air nationally on both ABC and ESPN. Joe Buck (play-by-play) will be in the booth alongside Troy Aikman (analyst). The game will stream live on the ESPN app, along with Fubo, which offers a free trial.

The NFL season continues in Week 11 when the San Francisco 49ers host the Arizona Cardinals on Sunday. Start time, how to watch, streaming and NFL schedule.