A human model of immune-driven liver injury Some drugs that pass early safety testing can still cause idiosyncratic drug-induced liver injury (iDILI)—a rare immune reaction that can lead to severe ...

Human periportal assembloid, showcasing the three key cell types of the liver: portal fibroblasts (magenta), cholangiocytes (green), and hepatocyte nuclei (blue). All cell borders are delineated in ...

CINCINNATI—Researchers at Cincinnati Children’s Hospital Medical Center in collaboration with Roche, have developed a next-generation human liver organoid microarray platform that that could help ...

Liver failure is one of the most serious and deadly medical conditions, claiming thousands of lives each year as patients in the United States wait for a donor organ. An up to $25.8 million research ...

One reason why our livers excel at clearing waste from our blood system is that the organ functions according to three key "zones" that perform specific major tasks. So, if scientists hope to create ...

For decades, animal models have been the gold standard for preclinical testing of potential drugs. Yet, even the best animal models are not perfect. For example, small rodent species with engrafted ...