Cancer cells are often described as “glutamine addicted,” relying heavily on this amino acid to fuel growth. But new research reveals how some tumors sidestep this vulnerability.
A new study shows cancer cells depend on vitamin B7 to use pyruvate as backup fuel, opening new strategies for targeted therapy.
Endogenous pyruvate is an end-product in glycolysis and a key molecule for ATP production under aerobic and anaerobic conditions, whereas exogenous pyruvate is transferred to cells via monocarboxylate ...