Dallas, TX - Two tiny randomized trials add to burgeoning observational and mechanistic evidence in favor of adding sildenafil, and perhaps other type-5 phosphodiesterase (PDE-5) inhibitors, to ...

Working with lab animals and human heart cells, scientists have identified what they describe as "the long-sought culprit" in the mystery behind a cell-signaling breakdown that triggers heart failure.

In the 1990s, the Pfizer cardiovascular (CV) research group in the UK was looking for new drugs to treat cardiovascular disease. This group had already scored some major successes in this area most ...

"As more and more patients seek therapy for sexual dysfunction, it is increasingly important for clinicians in a wide range of specialties to become proficient in the mechanisms and systemic effects ...

Taking a cue from the way drugs like Viagra put the biological brakes on a key enzyme involved in heart failure, scientists at Johns Hopkins have mapped out a key chemical step involved in blocking ...