Eukaryotic nuclear DNA is not only the template for gene transcription but also the substrate and platform for many biological processes. DNA needs to be structurally organized, repaired if damaged, ...

CpG density and epigenetic modification state modulate DNA mechanics, altering its intrinsic compatibility with nucleosome formation.

In a review published in Current Opinion in Structural Biology on May 12, researchers from the Institute of Biophysics of the Chinese Academy Sciences have reviewed the intricate molecular ...

Clinical outcome of patients (Pts) with metastatic renal cell carcinoma (mRCC) progressing on front-line immune-oncology based combination (IO-COMBO) regimens. This is an ASCO Meeting Abstract from ...

Nucleosome core particles have been efficiently assembled in vitro by direct interaction of histones and DNA at physiological ionic strength, as assayed by digestion with DNases, supercoiling of ...

Individual cells divide through a process called mitosis, during which the cell's copied DNA is separated between two resulting daughter cells. Despite recent advances in cell biology, the mechanism ...