Nearly every aspect of cellular behaviour and properties can be altered by the production of erroneous proteins. This situation holds true for cells of every living organism from the simplest ...
The Glickman lab, in close collaboration with the Shuman lab, is broadly interested in the pathways and regulation of DNA repair in mycobacteria. Our goals in the DNA repair arena are twofold: 1) to ...
In a recent study posted to the bioRxiv * pre-print server, a team of researchers demonstrated multiple site-directed mutagenesis as an efficient, easy, and more economically viable alternative to ...
Site-directed mutagenesis (SDM) is a commonly used technique for introducing mutations into a gene of interest. Existing techniques for SDM, such as whole plasmid SDM, while effective, are time ...
Scientists are finding new ways to improve the use of the CRISPR enzyme Cas9 and reduce the chances of off-target mutations in laboratory mice, according to new results. The findings will help ...
Site-directed mutagenesis (SDM) has been an important feature of the research landscape since its introduction in 1995. Continuing improvements to Pfu DNA polymerase have led to enhancements in the ...
Evolution is a virus’s secret weapon. The virus can rapidly slip on new disguises to evade our immune systems, and it can become resistant to antiviral drugs. But some scientists are turning the virus ...
This comprehensive book covers the underlying scientific principles, state of the art technologies and methodologies of plant mutagenesis. It covers historical development and commonly used ...
Site-directed mutagenesis facilitates the experimental validation of gene function and can speed up plant breeding by producing new biodiversity or by reproducing previously known gene variants in ...
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