Methotrexate is a chemotherapeutic agent used as medical therapy for the treatment of ectopic pregnancy. Although it is most commonly administered intramuscularly, obstetricians may inject the ...

The intracellular polyglutamation of methotrexate (MTX) is emerging as a crucial biochemical process in rheumatoid arthritis (RA) therapy. MTX polyglutamates (MTX-PGs) are metabolites formed by the ...

For initial treatment of symptomatic pulmonary sarcoidosis, methotrexate appeared to work as well as prednisone over 24 weeks, the randomized PREDMETH trial showed. Mean change from baseline in the ...

Please provide your email address to receive an email when new articles are posted on . Methotrexate use at the pre-arthritis stage of symptoms and subclinical inflammation fails to prevent clinical ...

foot gout Researchers prospectively examined the efficacy and safety of pegloticase in patients with uncontrolled gout who also received oral methotrexate. Methotrexate (MTX) and pegloticase ...

Adalimumab monotherapy and combination with methotrexate showed similar drug survival and PASI75 response rates in plaque psoriasis patients. Methotrexate reduced antidrug antibody levels but did not ...

The findings add complexity to questions about the long-term impact of acute lymphoblastic leukemia (ALL) therapy. A new report shows high cumulative doses of intravenous methotrexate can have ...

In July 2022, the US Food and Drug Administration (FDA) expanded the labeling of Krystexxa (pegloticase; Horizon Therapeutics), a PEGylated uric acid-specific enzyme, to include coadministration with ...

Researchers at the School of Chinese Medicine, LKS Faculty of Medicine, the University of Hong Kong (HKUMed), have found that combining the active ingredient extracted from the traditional Chinese ...

An article published in the International Journal of Dermatology evaluated the drug survival of methotrexate in patients with psoriasis. This single-center retrospective study assessed the clinical ...