Ducharme is a contributor to TIME. Ducharme is a contributor to TIME. Soon after she started taking the drug methotrexate in February, Jennifer Crow noticed a significant improvement in her ...

A widely used treatment for rheumatoid arthritis may offer an unexpected cardiovascular benefit. Methotrexate has been a staple treatment for rheumatoid arthritis for decades, valued for its ability ...

Please provide your email address to receive an email when new articles are posted on . Methotrexate use at the pre-arthritis stage of symptoms and subclinical inflammation fails to prevent clinical ...

COPENHAGEN -- Methotrexate helped high-risk individuals with aching and inflamed joints, but who didn't yet have overt rheumatoid arthritis (RA), avoid that diagnosis for close to 2 years in a ...

Methotrexate significantly lowers systolic blood pressure in newly diagnosed RA patients compared to sulfasalazine, potentially reducing cardiovascular risk. The study provides prospective comparative ...

Please provide your email address to receive an email when new articles are posted on . Patients with RA treated with first-line upadacitinib over 5 years had greater reductions in disease activity vs ...

Methotrexate is the gold standard of care for RA, but it can also disrupt a pregnancy. In states with strict anti-abortion laws, some women with RA cannot get their routine medication easily or ...

The intracellular polyglutamation of methotrexate (MTX) is emerging as a crucial biochemical process in rheumatoid arthritis (RA) therapy. MTX polyglutamates (MTX-PGs) are metabolites formed by the ...

While a 1-year course of methotrexate improved physical function, pain, morning joint stiffness, and joint inflammation, it did not prevent the development of clinical arthritis. Among patients with ...

Lymphoproliferative disorders (LPDs) represent a spectrum of conditions characterised by the uncontrolled proliferation of lymphoid cells. In patients with rheumatoid arthritis, the long‐term use of ...

Denise Johnston stood in line at the pharmacy to pick up her monthly prescription of methotrexate, which she takes to relieve pain from her psoriatic arthritis. A month earlier, Johnston, 49, picked ...

Medically reviewed by Scott Zashin, MD Key Takeaways People taking methotrexate should avoid alcohol because it can increase the risk of liver damage.Some NSAIDs like aspirin should not be taken with ...