The faithful and complete replication of chromosomes is essential to maintain genetic stability and prevent the accumulation of cancer-promoting mutations. Replication forks are vulnerable to stalling ...

Accurate transmission of the genetic information requires complete duplication of the chromosomal DNA each cell division cycle. However, the idea that replication forks would form at origins of DNA ...

Replication forks encounter problems due to causes such as chemical damage to the DNA template, from both endogenous and exogenous agents, and problems with the protein–DNA complexes that are ...

A team of scientists has discovered the surprising manner in which an enigmatic protein known as SUUR acts to control gene copy number during DNA replication. It’s a finding that could shed new light ...

While scientists have had an idea of the molecular tools that cells use to replicate DNA -- the enzymes that unzip the double-stranded DNA and create 'daughter' copies -- they did not have a clear ...