Ancient protein Dicer and RNase H are both needed to resolve transcription–replication collisions, study reveals

Could yeast and humans be any more different? Going by looks alone, probably not. But peering into our genomes reveals ...
The Scientist

DNA Polymerase Works in Short Bursts Rather than One Long Stretch

Biology lectures teach students that when a cell’s replication machinery comes together, DNA polymerase takes off down the double-helix like a car on a highway ...

Rethinking how nucleoside supplementation speeds up DNA replication: It's not just about having enough

DNA, often called the blueprint of life, is built from four chemical building blocks known as deoxy-nucleoside triphosphates ...

First high-resolution structure of key herpes virus protein opens path to new antivirals

An international research team has determined the first high-resolution structures of the herpes simplex virus origin-binding ...
Brandeis University

Professor Steven Henikoff receives 55th Rosenstiel Award for research on genome organization and gene expression

The 55th Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research has been awarded to professor Steven ...
ascopubs.org

A phase 1/2 dose escalation study of the oral DNA polymerase theta inhibitor (POLQi) GSK4524101 ± niraparib in adults with advanced or metastatic solid tumors.

Trial in progress: First-in-human study of PFL-721/STX-721 in participants with locally advanced or metastatic non-small cell lung cancer harboring EGFR exon 20 insertion mutations. This is an ASCO ...

The real killer of Napoleon’s army revealed by DNA testing

However, recent microbial analysis conducted on the remains of Grand Army soldiers indicates at least two other pathogens ...