SGLT2 inhibitors (gliflozins) were developed as oral antidiabetics. They enhance urinary glucose excretion by inhibiting SGLT-2 (sodium-dependent glucose co-transporter-2) in the renal tubuli. The ...

Eleven of 13 patients with far advanced chronic renal disease of diverse etiologies were found to have urine that remained hypotonic to plasma in spite of the administration of a supramaximal dose of ...

In addition to the debate over the complex renal mechanisms involved in the pathogenesis of hypertension, there is continued controversy regarding the role of sodium intake in hypertension. In some ...

Renal fibrosis, particularly tubulointerstitial fibrosis, is the common final outcome of almost all progressive chronic kidney diseases. Renal fibrosis is also a reliable predictor of prognosis and a ...

Niigata, Japan - The gold standard test for predicting the onset of diabetic kidney disease is albuminuria. However, detecting albuminuria alone has limited sensitivity and specificity in end-stage ...

Urea transporter (UT) proteins facilitate the passive transport of urea driven by a concentration gradient across the cell plasma membrane in some kidney and extrarenal cells The kidney expresses ...

Researchers uncover a previously unrecognized mechanism that may accelerate polycystic kidney disease. For people with polycystic kidney disease (PKD), life can be a constant cycle of symptoms: aches ...

Polycystic kidney disease is a painful disorder. In this condition, clusters of non-cancerous fluid-filled sacs, called cysts, form in the kidneys. A person suffering from this condition experience ...