CTCF is widely recognized for its essential role in mediating chromatin loops to regulate gene expression, particularly by modulating enhancer-promoter (EP) interactions. However, acute depletion of ...

Dr. Yasuhiro Arimura studies chromatin, the mixture of DNA and DNA-packaging proteins. Chromatin is “marked” with numerous chemical or structural cues that enable cells to organize DNA and manage how ...

The Dere lab specializes in kidney cancer and VHL (von Hippel Lindau) disease focused on understand fundamental aspects of how non-chromatin functions of chromatin modifiers contribute to oncogenesis.

The biology of histone proteins encompasses their synthesis in the cytosol, nuclear import and incorporation into nucleosomes, as well as subsequent eviction from chromatin, redeposition, storage or ...

This Brush Up is sponsored by Cayman Chemical. Learn more about chemical inhibitors of histone modification. Histone modification affects how tightly DNA wraps around histone proteins, yielding ...