Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...

New research has identified the specific biological mechanism behind the muscle dysfunction found in myotonic dystrophy type 1 (DM1) and further shows that calcium channel blockers can reverse these ...

Biomedical engineers at Duke University have developed a new technique to better understand and test treatments for a group of extremely rare muscle disorders called dysferlinopathy or limb girdle ...

You’re relaxing on the sofa when suddenly your eyelid starts twitching. Or perhaps it’s a muscle in your arm, your leg, or your foot that begins to spasm – sometimes for a few seconds, sometimes for ...

Biomedical engineers have grown muscles in a lab to better understand and test treatments for a group of extremely rare muscle disorders called dysferlinopathy or limb girdle muscular dystrophies 2B ...

The top row of photos show a microscopic view of healthy muscle fibers stained to reveal a variety of irregularities, while the bottom row shows the same but for muscle fibers afflicted by the disease ...