Your MacBook comes with natural scrolling by default. This means when your fingers go upwards in the trackpad, the page scrolls downwards, and vice versa. This could be a big change, especially when ...
Apple's Mighty Mouse, despite its unique features, still uses a mechanical ball that is used for the navigation. Just like previous ball mice, this mechanism is prone to skip after a while of usage.
I don't remember how long ago exactly, Apple told us our scrolling was unnatural, and of course endeavored to rectify that mistake by introducing "natural scrolling". Now obviously moving your fingers ...