Anaphase in budding yeast is triggered by cleavage of the central subunit, Scc1, of the chromosomal cohesin complex by the protease separase. Here we show that separase also cleaves the ...

The anaphase promoting complex/cyclosome (APC/C) is a 1.5-MDa ubiquitin ligase complex that initiates sister-chromatid separation and exit from mitosis by targeting cyclin B and securin for ...

This is a preview. Log in through your library . Abstract During the movement of chromosomes in anaphase, microtubules that extend between the kinetochores and the poles shorten. We sought to ...

Cul3 (Cullin3)-based E3 ubiquitin ligases recently emerged as critical regulators of mitosis. In this study, we identify two mammalian BTB (Bric-a-brac—Tramtrack—Broad complex)-Kelch proteins, KLHL21 ...

What am I looking at? These images show a single cell in the middle dividing into two so-called daughter cells. The stage of the cell division process represented here is called anaphase. In these ...

Prognostic significance of circulating tumor cell (CTC) levels at various times during first- and second-line chemotherapy for metastatic breast cancer (MBC). This is an ASCO Meeting Abstract from the ...

Oncotarget published "NEDD8-activating enzyme inhibition induces cell cycle arrest and anaphase catastrophe in malignant T-cells" which reported that peripheral T-cell lymphoma is characterized by ...

As in anaphase in mitosis (and unlike anaphase I in meiosis), the fibers pull the chromatids apart and toward opposite ends of the cells.

Researchers have made an exciting discovery about how human cells protect DNA during cell division, offering new insights into combating diseases such as cancer. The research uncovers the vital role ...