The San Francisco 49ers do not expect to have receiver Brandon Aiyuk on the field for the season-opening game against the Seattle Seahawks on Sept. 7.

As for Aiyuk, Week 1 was always a long shot. It’ll be interesting to see if the 49ers keep a roster spot open and leave the door cracked for Aiyuk to return within the first four weeks. The other option would be to think big picture and place Aiyuk on the PUP list, where he’d return no sooner than Week 5.

Aiyuk was placed on the physically unable to perform list when training camp opened last month. The former first-round pick is recovering from a torn ACL and MCL he suffered in Week 7 against the Kansas City Chiefs during the 2024 season. If Aiyuk starts the regular season on the PUP list, he'd be required to miss at least four games.