Strumica is the largest city in southeastern North Macedonia, near the Novo Selo-Petrich border crossing with Bulgaria. About 54,676 peopl…Strumica is the largest city in southeastern North Macedonia, near the Novo Selo-Petrich border crossing with Bulgaria. About 54,676 people live in the region surrounding the city. It is named after the Strumica River which runs through it. The city of Strumica is the seat of Strumica Municipality.